Автор: Diandimov
Дата: 03-09-10 09:20
Цялата статия .
И откъси:
It remained freely available worldwide until the 1970s, when it was discovered that the drug carries a small risk of causing agranulocytosis - a potentially fatal condition.
Availability around the world
Metamizole was banned in Sweden in 1974, and in the United States in 1977. Since then, more than 30 countries (including Japan, Australia, Iran, and several of the European Union member nations) have followed suit. In these countries, metamizole is still occasionally used as a veterinary drug. In Germany, Hungary, Italy, Portugal and Spain it is a prescription drug. Some European pharmaceutical companies, notably Hoechst and Merck, continue to develop metamizole-containing drugs and market them in some countries. In Sweden, the ban was lifted in 1995 only to be re-introduced in 1999.
In other parts of the world (including Bulgaria, Mexico, India, Egypt, Brazil, Poland, Russia, Turkey, the Republic of Macedonia, Romania, Israel, and some developing countries) metamizole is still freely available over-the-counter, remains one of the most popular analgesics, and plays an important role in self-medication. For example, metamizole and metamizole-containing drugs account for 80% of OTC analgesic market in Russia, whereas ibuprofen accounts for 2.5%. In Brazil, metamizole (Novalgina) products, although over-the-counter, carry warnings to avoid usage by those under 19 years old, and include some information about early detection and treatment of agranulocytosis. Although the Brazilian government did not push for a ban on the drug, its use has seen a decline in the past years as pharmaceutical companies and doctors pushed aspirin, paracetamol and ibuprofen-based products as replacement, especially regarding child care. Amongst adults it is still widely used. Some of the most widely available metamizole-containing products still in use in Brazil are: Buscopan Plus (under the name of Buscopan Composto), Novalgina and Neosaldina. Generic Dipyrone is also available.
Metamizole has such high usage in Brazil, that in late 2008 Sanofi-aventis released a new version of the product with 1 g of metamizole per tablet (twice the normal 500 mg dosage available before), still under the Novalgina name.
In Israel, Metamizole is used as the first level of pain treatment in hospitals, and is given in standard, over-the-counter doses. (In the US, the first-level painkiller is usually ibuprofen, given in doses that are 120–200% of the over-the-counter dose.)
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